[HTML][HTML] The role of alternative splicing in cancer: From oncogenesis to drug resistance

R Sciarrillo, A Wojtuszkiewicz, YG Assaraf… - Drug Resistance …, 2020 - Elsevier
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

A Sveen, S Kilpinen, A Ruusulehto, RA Lothe… - Oncogene, 2016 - nature.com
Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Molecular map of chronic lymphocytic leukemia and its impact on outcome

BA Knisbacher, Z Lin, CK Hahn, F Nadeu… - Nature …, 2022 - nature.com
Recent advances in cancer characterization have consistently revealed marked
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …

Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types

M Seiler, S Peng, AA Agrawal, J Palacino, T Teng… - Cell reports, 2018 - cell.com
Hotspot mutations in splicing factor genes have been recently reported at high frequency in
hematological malignancies, suggesting the importance of RNA splicing in cancer. We …

Non-coding recurrent mutations in chronic lymphocytic leukaemia

XS Puente, S Beà, R Valdés-Mas, N Villamor… - Nature, 2015 - nature.com
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer

T Ouspenskaia, T Law, KR Clauser, S Klaeger… - Nature …, 2022 - nature.com
Tumor-associated epitopes presented on MHC-I that can activate the immune system
against cancer cells are typically identified from annotated protein-coding regions of the …

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

CC Oakes, M Seifert, Y Assenov, L Gu… - Nature …, 2016 - nature.com
Charting differences between tumors and normal tissue is a mainstay of cancer research.
However, clonal tumor expansion from complex normal tissue architectures potentially …

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

A Pellagatti, RN Armstrong, V Steeples… - Blood, The Journal …, 2018 - ashpublications.org
Abstract SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in
the myelodysplastic syndromes (MDS). We have performed a comprehensive and …

Chronic lymphocytic leukaemia

TJ Kipps, FK Stevenson, CJ Wu, CM Croce… - Nature reviews Disease …, 2017 - nature.com
Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized
by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and …

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

W Zhang, Y Yu, F Hertwig, J Thierry-Mieg, W Zhang… - Genome biology, 2015 - Springer
Background Gene expression profiling is being widely applied in cancer research to identify
biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for …