Broken detailed balance and non-equilibrium dynamics in living systems: a review

FS Gnesotto, F Mura, J Gladrow… - Reports on Progress in …, 2018 - iopscience.iop.org
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …

Time irreversibility in active matter, from micro to macro

J O'Byrne, Y Kafri, J Tailleur, F van Wijland - Nature Reviews Physics, 2022 - nature.com
Active matter encompasses systems whose individual constituents dissipate energy to exert
propelling forces on their environment. These systems exhibit dynamical phenomena with …

Quantifying dissipation using fluctuating currents

J Li, JM Horowitz, TR Gingrich, N Fakhri - Nature communications, 2019 - nature.com
Abstract Systems coupled to multiple thermodynamic reservoirs can exhibit nonequilibrium
dynamics, breaking detailed balance to generate currents. To power these currents, the …

Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

X Yang, M Heinemann, J Howard… - Proceedings of the …, 2021 - National Acad Sciences
Cells are the basic units of all living matter which harness the flow of energy to drive the
processes of life. While the biochemical networks involved in energy transduction are well …

Improved bounds on entropy production in living systems

DJ Skinner, J Dunkel - … of the National Academy of Sciences, 2021 - National Acad Sciences
Living systems maintain or increase local order by working against the second law of
thermodynamics. Thermodynamic consistency is restored as they consume free energy …

Variance sum rule for entropy production

I Di Terlizzi, M Gironella, D Herráez-Aguilar, T Betz… - Science, 2024 - science.org
Entropy production is the hallmark of nonequilibrium physics, quantifying irreversibility,
dissipation, and the efficiency of energy transduction processes. Despite many efforts, its …

Intertwined and finely balanced: endoplasmic reticulum morphology, dynamics, function, and diseases

HT Perkins, V Allan - Cells, 2021 - mdpi.com
The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

Learning force fields from stochastic trajectories

A Frishman, P Ronceray - Physical Review X, 2020 - APS
When monitoring the dynamics of stochastic systems, such as interacting particles agitated
by thermal noise, disentangling deterministic forces from Brownian motion is challenging …

Inferring broken detailed balance in the absence of observable currents

IA Martínez, G Bisker, JM Horowitz… - Nature …, 2019 - nature.com
Identifying dissipation is essential for understanding the physical mechanisms underlying
nonequilibrium processes. In living systems, for example, the dissipation is directly related to …

Theoretical perspectives on biological machines

ML Mugnai, C Hyeon, M Hinczewski… - Reviews of Modern Physics, 2020 - APS
Many biological functions are executed by molecular machines, which like man-made
motors are powered by chemical energy, released by adenosine triphosphate hydrolysis …