[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics
U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …
produce aggressive malignancies that causes millions of deaths every year. With the new …
Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress
S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …
[HTML][HTML] Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …
many factors and a huge energy investment from the cell. Ribosomes are essential for …
Nucleophosmin: from structure and function to disease development
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …
Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes
Mammalian oocytes spend most of their life in a unique state of cell cycle arrest at meiotic
prophase I, during which time they are exposed to countless DNA-damaging events. Recent …
prophase I, during which time they are exposed to countless DNA-damaging events. Recent …
[HTML][HTML] Molecular changes in endometriosis-associated ovarian clear cell carcinoma
MJ Worley Jr, S Liu, Y Hua, JSL Kwok, A Samuel… - European Journal of …, 2015 - Elsevier
Background Endometriosis is frequently associated with and thought of having propensity to
develop into ovarian clear cell carcinoma (OCCC), although the molecular transformation …
develop into ovarian clear cell carcinoma (OCCC), although the molecular transformation …
The targeting of RNA polymerase I transcription using CX-5461 in combination with radiation enhances tumour cell killing effects in human solid cancers
An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied
by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard …
by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard …
[HTML][HTML] Endometriosis-associated ovarian clear cell carcinoma: a special entity?
Y Sun, G Liu - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Endometriosis is an estrogen-dependent disease, which serves as a precursor of ovarian
cancer, especially clear cell carcinoma (OCCC) and endometrial carcinoma. Although micro …
cancer, especially clear cell carcinoma (OCCC) and endometrial carcinoma. Although micro …
Identification of microRNA‐96‐5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma
T Matsui, S Hamada‐Tsutsumi, Y Naito… - Hepatology …, 2022 - Wiley Online Library
Abstract Aim The microRNA (miR) clusters miR‐183/96/182 and miR‐217/216a/216b are
significantly upregulated in nonviral hepatocellular carcinoma (NBNC‐HCC). Here, we …
significantly upregulated in nonviral hepatocellular carcinoma (NBNC‐HCC). Here, we …
Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy
K Seborova, V Hlavac, P Holy, SS Bjørklund… - Frontiers in …, 2022 - frontiersin.org
Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced
stages and frequent therapy resistance. Previous findings suggested that the DNA repair …
stages and frequent therapy resistance. Previous findings suggested that the DNA repair …