Immune checkpoint inhibitors, including those targeting CTLA‐4/B7 and the PD‐1/PD‐L1
inhibitory pathways, are now available for clinical use in cancer patients, with other …

Photodynamic therapy (PDT) is a photochemistry based treatment modality that involves the
generation of cytotoxic species through the interactions of a photosensitizer molecule with …

Summary Background Pembrolizumab (PD-1 inhibitor) and cetuximab (EGFR inhibitor) are
active as single agents and in combination with cytotoxic chemotherapy for recurrent or …

Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …

Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

Background Cetuximab is effective in platinum-resistant recurrent or metastatic squamous-
cell carcinoma of the head and neck. We investigated the efficacy of cetuximab plus …

An unmet need in cell engineering is the availability of a single transgene encoded,
functionally inert, human polypeptide that can serve multiple purposes, including ex vivo cell …

Cetuximab, an antibody directed against the epidermal growth factor receptor, is an effective
clinical therapy for patients with colorectal, head and neck, and non–small cell lung cancer …

Functional activation of growth factors and receptors of the epidermal growth factor receptor
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer …

Background Findings from the phase 3 First-Line ErbituX in lung cancer (FLEX) study
showed that the addition of cetuximab to first-line chemotherapy significantly improved …