Over the past 30 years the mitochondrial permeability transition–the permeabilization of the
inner mitochondrial membrane due to the opening of a wide pore–has progressed from …

Highlights•Mitochondrial permeability transition pore (mPTP) has been considered as a key
cell death inducing process in several neurodegenerative diseases.•Studies suggest that …

Abstract F 1 FO ATP synthase is responsible for the production of> 95% of all ATP synthesis
within the cell. Dysregulation of its expression, activity or localization is linked to various …

Mitochondria have been linked to the etiology of schizophrenia (SZ). However, studies of
mitochondria in SZ might be confounded by the effects of pharmacological treatment with …

The present study examines the possible inhibitory effect of JM-20, a multi-target
neuroprotective compound, on the development of morphine-induced hyperalgesia in Male …

We previously showed that JM-20, a novel 1, 5-benzodiazepine fused to a dihydropyridine
moiety, possessed an anxiolytic profile similar to diazepam and strong neuroprotective …

The number of people with dementia worldwide is estimated at 50 million by 2018 and
continues to rise mainly due to increasing aging and population growth. Clinical impact of …

Because mitochondrial oxidative stress and impairment are important mediators of neuronal
damage in neurodegenerative diseases and in brain ischemia/reperfusion, in the present …

Stroke is frequently associated with severe neurological decline and mortality, and its
incidence is expected to increase due to aging population. The only available …

Cerebral ischemia is the third most common cause of death and a major cause of disability
worldwide. Beyond a shortage of essential metabolites, ischemia triggers many …