Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Several studies support currently the hypothesis that autism etiology is based on a polygenic
and epistatic model. However, despite advances in epidemiological, molecular and clinical …

The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic
glutamate receptors (mGlus), which are class CG protein–coupled receptors (GPCRs). We …

Tuberous sclerosis complex and fragile X syndrome are genetic diseases characterized by
intellectual disability and autism. Because both syndromes are caused by mutations in …

Prevention of epileptogenesis after brain trauma is an unmet medical challenge. Recent
molecular profiling studies have provided an insight into molecular changes that contribute …

Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …

Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …

The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) induces
excitatory synapse elimination in mouse neurons, which requires fragile X mental …

The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

Objective: Minocycline rescued synaptic abnormalities and improved behavior in the fragile
X mouse model. Previous open-label human studies demonstrated benefits in individuals …