Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: novel targets for therapy

LM Khachigian, BL Black, P Ferdinandy… - Vascular …, 2022 - Elsevier
Vascular smooth muscle cells (SMC) possess a unique cytoplasticity, regulated by
transcriptional, translational and phenotypic transformation in response to a diverse range of …

Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis

J Yao, L Cai, Y Chen, J Zhang, W Zhuang… - Cell Communication and …, 2022 - Springer
Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly
due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells …

Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis Corrigendum in/10.3892/ijmm. 2023.5267

X Liu, Y Wu, Z Zhou, M Huang… - International …, 2019 - spandidos-publications.com
Celecoxib, a selective cyclooxygenase‑2 inhibitor, has chemo‑preventive activity against
different cancer types, including bladder cancer (BC). However, the mechanisms by which …

c‐Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR‐145‐5p/SPOP/PD‐L1 axis

L Zhang, X Wang, Y Li, J Han, X Gao… - Clinical and …, 2021 - Wiley Online Library
Esophageal adenocarcinoma (EAC), a subtype of esophageal carcinoma, is a severe health
problem associated with high death rate and poor prognosis. Immunotherapy has proven to …

miR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4

X Xie, T Shirasu, J Li, LW Guo, KC Kent - Cell Death Discovery, 2023 - nature.com
Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-
stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic …

Hsa‐miRNA‐143‐3p regulates the odontogenic differentiation of human stem cells from the apical papilla by targeting NFIC

S Gao, LH Ge, YM Zhao, P Li, Y Li… - International Endodontic …, 2022 - Wiley Online Library
Aim To evaluate the effects of hsa‐miRNA‐143‐3p on the cytodifferentiation of human stem
cells from the apical papilla (hSCAPs) and the post‐transcriptional regulation of Nuclear …

Biomarkers in VSMC phenotypic modulation and vascular remodeling

Y Qi, F Dai, J Gu, W Yao - Die Pharmazie-An International …, 2019 - ingentaconnect.com
Vascular smooth muscle cells (VSMCs) are not terminally differentiated and can change
their phenotype in response to environmental cues. Phenotype switching of VSMCs to less …

[HTML][HTML] Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers

I Moscoso, M Rodríguez-Mañero… - International Journal of …, 2024 - mdpi.com
Cardiotoxicity (CDTX) is a critical side effect of many cancer therapies, leading to increased
morbidity and mortality if not addressed. Early detection of CDTX is essential, and while …

Exosomes and lipid metabolism in metabolic and cardiovascular disorders

ZZ Abdin, AZ Geng, M Chandy - Current Opinion in Lipidology, 2023 - journals.lww.com
Recent advances in our understanding of exosomes and lipid metabolism have implications
for our understanding of normal cellular and physiological functions as well as disease …

A tangled tale of microRNA and cardiac fibrosis

M Chandy - Clinical Science, 2019 - portlandpress.com
Cardiac fibrosis is important for wound healing, regeneration and producing the extracellular
matrix (ECM) that provides the scaffold for cells. In pathological situations, fibroblasts are …