BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

Trp63, a transcription factor related to the tumor suppressor p53, is activated by diverse
stimuli and can initiate a range of cellular responses. TAp63 is the predominant Trp53 family …

BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …

The generation of haploid gametes by meiosis is a highly conserved process for sexually
reproducing organisms that, in almost all cases, involves the extensive breakage of …

Chromosome segregation errors in human oocytes lead to aneuploid embryos that cause
infertility and birth defects. Here we provide an overview of the chromosome-segregation …

STUDY QUESTION Does female ageing have a negative effect on the DNA repair capacity
of oocytes fertilised by spermatozoa with controlled levels of DNA damage? SUMMARY …

BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …

Genetic material is constantly subjected to genotoxic insults and is critically dependent on
DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma …