Lipotoxicity drives the development of progressive hepatic inflammation and fibrosis in a
subgroup of patients with nonalcoholic fatty liver disease (NAFLD), causing nonalcoholic …

Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …

Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by
upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription …

Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …

Ethnopharmacological relevance Rutin is a common dietary flavonoid that is widely
consumed from plant-derived beverages and foods as traditional and folkloric medicine …

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of hepatic
histopathological changes ranging from non-inflammatory intracellular fat deposition to non …

Emerging experimental and human evidence has linked altered hepatic cholesterol
homeostasis and free cholesterol (FC) accumulation to the pathogenesis of non-alcoholic …

As many diseases have been shown to have several or indirect causes (ie are multifactorial)
the question is what is the relative importance of each factor in a given disease? Also, what …

Cholesterol is a crucial component of membrane bilayers by regulating their structural and
functional properties. Cholesterol traffics to different cellular compartments including …