In 2004, the US Food and Drug Administration (FDA) released an important report entitled
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …

Chromones are a group of naturally occurring compounds that are ubiquitous in nature,
especially in plants. The word chromone is derived from the Greek word chroma, meaning …

METHODS: Treatment consisted of a continuous dosing schedule of oral sirolimus starting at
0.8 mg/m 2 per dose twice daily, with pharmacokinetic-guided target serum trough levels of …

The serine/threonine kinase Akt lies at a critical signaling node downstream of
phosphatidylinositol-3-kinase and is important in promoting cell survival and inhibiting …

MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important roles in
various cellular functions and tumor development. Recent studies have indicated that miR …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

Abstract MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majority of its
reported targets are tumor suppressors. Through functional suppression, miR-21 is …

Ovarian cancer is the leading cause of death from gynaecological malignancies in the
Western world. Despite the evolution of surgical techniques and meticulously designed …

Heat-shock proteins (HSPs) are molecular chaperones that regulate protein folding to
ensure correct conformation and translocation and to avoid protein aggregation. Heat-shock …

Protein/peptide drugs possess unique advantages, such as high pharmacological potency,
molecular specificity, multifunctionality, and low toxicity, and thus hold great potential for use …