Interactions of IDO and the kynurenine pathway with cell transduction Systems and metabolism at the inflammation–cancer interface

TW Stone, RO Williams - Cancers, 2023 - mdpi.com
Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …

The emerging, multifaceted role of WTAP in Cancer and Cancer Therapeutics

G Ju, J Lei, S Cai, S Liu, X Yin, C Peng - Cancers, 2023 - mdpi.com
Simple Summary N6-methyladenosine (m6A) modification is among the most common and
conservative RNA modifications in eukaryotes. The deposition of m6A on RNA is carried out …

[HTML][HTML] M6A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer

X Liu, P Li, Y Huang, H Li, X Liu, Y Du, X Lin, D Chen… - Redox Biology, 2024 - Elsevier
Resistance to chemotherapy is the main reason for treatment failure and poor prognosis in
patients with triple-negative breast cancer (TNBC). Although the association of RNA N6 …

Interleukin-17 directly stimulates tumor infiltrating Tregs to prevent cancer development

WC Theune, J Chen, EV Theune, X Ye… - Frontiers in …, 2024 - frontiersin.org
Background Interleukin-17 (IL-17) family cytokines promote protective inflammation for
pathogen resistance, but also facilitate autoimmunity and tumor development. A direct signal …

Tregs in transplantation tolerance: role and therapeutic potential

A Cassano, AS Chong, ML Alegre - Frontiers in Transplantation, 2023 - frontiersin.org
CD4+ Foxp3+ regulatory T cells (Tregs) are indispensable for preventing autoimmunity, and
they play a role in cancer and transplantation settings by restraining immune responses. In …

The role and mechanism of m6A methylation in diabetic nephropathy

L Yan, L Guo - Life Sciences, 2025 - Elsevier
Diabetic nephropathy (DN) is one of the most common microvascular complications of
diabetes mellitus, characterized by progressive deterioration of renal structure and function …

Chirality Regulates Macrophage Polarization for Tissue Regeneration Through Bidirectionally Modulating WTAP‐Mediated m6A Modification

Y Yang, X Guo, C Huang, C Chen, Y Zhou… - Small …, 2024 - Wiley Online Library
Chirality, a fundamental design feature at all levels of life organization, has shown great
capability in guiding cell‐fate determination and tissue regeneration. Chirality‐directed …

New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma

Y Li, Y Qiu, M Li, M Shen, F Zhang, J Shao… - Acta Pharmacologica …, 2024 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common malignancy, presenting a
formidable challenge to the medical community owing to its intricate pathogenic …

WTAP promotes the progression of ulcerative colitis by silencing the expression of CES2 through m6A modification

X Xie, S Cheng, X Chen, X Wang - Journal of Autoimmunity, 2024 - Elsevier
Objective This study will explore the function of WTAP, the critical segment of m 6 A
methyltransferase complex, in UC and its regulation on immune response. Methods The …

A comprehensive analysis of m6A/m7G/m5C/m1A-related gene expression and immune infiltration in liver ischemia–reperfusion injury by integrating bioinformatics …

Z Meng, X Li, S Lu, Y Hua, B Yin, B Qian, Z Li… - European Journal of …, 2024 - Springer
Background Liver ischemia–reperfusion injury (LIRI) is closely associated with immune
infiltration, which commonly occurs after liver surgery, especially liver transplantation …