Substance use disorders (SUDs) are highly prevalent. SUDs involve vicious cycles of binges
followed by occasional periods of abstinence with recurrent relapses despite treatment and …

Rationale and objectives Addiction to psychostimulant methamphetamine (METH) remains a
major public health problem in the world. Animal models that use METH self-administration …

Background Methamphetamine is a neuro-stimulant with neurodegenerative effects, and
ambiguous mechanism of action. Metformin is an antidiabetic agent with neuroprotective …

In a rat model of drug craving and relapse, cue-induced drug seeking progressively
increases after withdrawal from methamphetamine and other drugs, a phenomenon termed …

Clinical and preclinical studies have indicated that chronic methamphetamine (MA) use is
associated with extensive neurodegeneration, psychosis, and cognitive impairment …

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and
powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field …

Amphetamine and methamphetamine addiction is described by specific behavioral
alterations, suggesting long-lasting changes in gene and protein expression within specific …

Methamphetamine-associated cardiomyopathy is the leading cause of death linked with
illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine …

Abstract Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with
dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies …

Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …