In the recent era, no congenital heart defect has undergone a more dramatic change in
diagnostic approach, management, and outcomes than hypoplastic left heart syndrome …

Hypoplastic left heart syndrome is a rare congenital heart defect in which the left side of the
heart is underdeveloped. Surgical management of hypoplastic left heart syndrome has …

Background The Norwood procedure with a modified Blalock–Taussig (MBT) shunt, the first
palliative stage for single-ventricle lesions with systemic outflow obstruction, is associated …

Background—Survivors of the Norwood procedure may experience neurodevelopmental
impairment. Clinical trials to improve outcomes have focused primarily on methods of vital …

Background Outcome of stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS)
has improved coincident with application of treatment strategies including continuous …

OBJECTIVE: To determine whether early identification of physiologic variances associated
with interstage death would reduce mortality, we developed a home surveillance program …

Background—Hypoplastic left heart syndrome (HLHS) with intact or very restrictive atrial
septum is a highly lethal combination. We review our 13-year institutional experience …

Rodent models have been essential to understanding the immune‐mediated failure of aortic
valve allografts (AVAs). Decellularization has been proposed to reduce the immunogenicity …

Background—Since the initial utilization of heart transplantation as therapy for end-stage
pediatric heart disease, improvements have occurred in outcomes with heart transplantation …

OBJECTIVE: Tremendous strides have been made in the outcomes for hypoplastic left heart
syndrome and other functional single-ventricle malformations over the past 25 years. This …