CTCF shapes chromatin structure and gene expression in health and disease
B Dehingia, M Milewska, M Janowski, A Pękowska - EMBO reports, 2022 - embopress.org
CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
CTCF: making the right connections
R Ghirlando, G Felsenfeld - Genes & development, 2016 - genesdev.cshlp.org
The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now
well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin …
well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin …
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation
N Kubo, H Ishii, X Xiong, S Bianco… - Nature structural & …, 2021 - nature.com
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …
formation of chromatin loops and topologically associating domains, but its role in gene …
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function
CTCF and the associated cohesin complex play a central role in insulator function and
higher-order chromatin organization of mammalian genomes. Recent studies identified a …
higher-order chromatin organization of mammalian genomes. Recent studies identified a …
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
S Shukla, E Kavak, M Gregory, M Imashimizu… - Nature, 2011 - nature.com
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in
eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co …
eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co …
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment
CTCF is an architectural protein with a critical role in connecting higher-order chromatin
folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more …
folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more …
Widespread plasticity in CTCF occupancy linked to DNA methylation
CTCF is a ubiquitously expressed regulator of fundamental genomic processes including
transcription, intra-and interchromosomal interactions, and chromatin structure. Because of …
transcription, intra-and interchromosomal interactions, and chromatin structure. Because of …
Complexity of chromatin folding is captured by the strings and binders switch model
M Barbieri, M Chotalia, J Fraser… - Proceedings of the …, 2012 - National Acad Sciences
Chromatin has a complex spatial organization in the cell nucleus that serves vital functional
purposes. A variety of chromatin folding conformations has been detected by single-cell …
purposes. A variety of chromatin folding conformations has been detected by single-cell …
[HTML][HTML] Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
CTCF-binding locations represent regulatory sequences that are highly constrained over the
course of evolution. To gain insight into how these DNA elements are conserved and spread …
course of evolution. To gain insight into how these DNA elements are conserved and spread …