Vitamin K–sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity

P Mladěnka, K Macáková, L Kujovská Krčmová… - Nutrition …, 2022 - academic.oup.com
Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also …

[HTML][HTML] Role of vitamin K in intestinal health

Y Lai, H Masatoshi, Y Ma, Y Guo, B Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer
(CRC) generally characterized by clinical symptoms, including malabsorption, intestinal …

[HTML][HTML] Vitamin E and metabolic health: Relevance of interactions with other micronutrients

S Liao, SO Omage, L Börmel, S Kluge, M Schubert… - Antioxidants, 2022 - mdpi.com
A hundred years have passed since vitamin E was identified as an essential micronutrient
for mammals. Since then, many biological functions of vitamin E have been unraveled in …

[HTML][HTML] Targeting a silent disease: Vascular calcification in chronic kidney disease

C Marreiros, C Viegas, D Simes - International Journal of Molecular …, 2022 - mdpi.com
Chronic kidney disease (CKD) patients have a higher risk of developing early
cardiovascular disease (CVD). Although vascular calcification (VC) is one of the strongest …

[HTML][HTML] Vitamin K supplementation for prevention of vascular calcification in chronic kidney disease patients: are we there yet?

S Roumeliotis, A Duni, V Vaios, A Kitsos… - Nutrients, 2022 - mdpi.com
Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial
calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In …

[HTML][HTML] Vitamin K supplementation and vascular calcification: a systematic review and meta-analysis of randomized controlled trials

T Li, Y Wang, W Tu - Frontiers in Nutrition, 2023 - frontiersin.org
Background: Vascular calcification is a complex process that has been linked to conditions
including cardiovascular diseases and chronic kidney disease. There is ongoing debate …

[HTML][HTML] Perspective: evidence before enthusiasm—a critical review of the potential cardiovascular benefits of vitamin K

MK Shea, KL Berkner, G Ferland, X Fu, RM Holden… - Advances in …, 2021 - Elsevier
ABSTRACT A protective role for vitamin K in cardiovascular disease (CVD), a leading cause
of morbidity and mortality, has been proposed because vitamin K–dependent proteins, such …

[HTML][HTML] Vitamin K and Hallmarks of Ageing: Focus on Diet and Gut Microbiome

L Dai, D Mafra, PG Shiels, TM Hackeng, P Stenvinkel… - Nutrients, 2023 - mdpi.com
Vitamin K and vitamin K-dependent proteins have been reported to be associated with a
large spectrum of age-related diseases. While most of these associations have been …

[HTML][HTML] Niacin–a scoping review for Nordic Nutrition Recommendations 2023

R Freese, V Lysne - Food & nutrition research, 2023 - ncbi.nlm.nih.gov
Niacin is the precursor to pyridine nucleotides NAD (nicotinamide adenine dinucleotide) and
NADP (nicotinamide adenine dinucleotide phosphate). Niacin (vitamin B 3) is the common …

Inhibit progression of coronary artery calcification with vitamin K in hemodialysis patients (the iPACK-HD study): a randomized, placebo-controlled multi-center, pilot …

RM Holden, SL Booth, D Zimmerman… - Nephrology Dialysis …, 2023 - academic.oup.com
Background Vitamin K activates matrix Gla protein (MGP), a key inhibitor of vascular
calcification. There is a high prevalence of sub-clinical vitamin K deficiency in patients with …