Glutamate and GABA homeostasis and neurometabolism in major depressive disorder

A Sarawagi, ND Soni, AB Patel - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health

C AnaMaria, DC Vodnar - Progress in Neuro-Psychopharmacology and …, 2024 - Elsevier
One of the most challenging and controversial issues in microbiome research is related to
gut microbial metabolism and neuropsychological disorders. Psychobiotics affect human …

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

JT Kantrowitz, Z Dong, MS Milak, R Rashid… - Translational …, 2021 - nature.com
Glutamate (Glu) and gamma-aminobutyric acid (GABA) are implicated in the
pathophysiology of major depressive disorder (MDD). GABA levels or GABAergic …

Examining and modulating neural circuits in psychiatric disorders with transcranial magnetic stimulation and electroencephalography: present practices and future …

F Ferrarelli, ML Phillips - American Journal of Psychiatry, 2021 - Am Psychiatric Assoc
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique
uniquely equipped to both examine and modulate neural systems and related cognitive and …

Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial

GA Narayan, KR Hill, K Wengler, X He, J Wang… - Molecular …, 2022 - nature.com
Previous proton magnetic resonance spectroscopy (1H-MRS) studies suggest a perturbation
in glutamate and/or GABA in Major Depressive Disorder (MDD). However, no studies …

The microbiota-gut-brain axis in pathogenesis of depression: A narrative review

H Yao, D Zhang, H Yu, H Shen, H Liu, F Meng… - Physiology & …, 2023 - Elsevier
The microbiota-gut-brain axis is a bidirectional regulatory pathway between the brain and
the gastrointestinal tract, which plays an important role in maintain homeostasis. Gut …

[HTML][HTML] The effects of polyethylene microplastics on the growth, reproduction, metabolic enzymes, and metabolomics of earthworms Eisenia fetida

X Yang, X Zhang, X Shu, J Gong, J Yang, B Li… - Ecotoxicology and …, 2023 - Elsevier
The existing data regarding the effects of polyethylene (PE) microplastics (MPs) smaller than
5 mm in size on earthworms are insufficient to fully comprehend their toxicity. In this study …

Fronto-limbic neuroimaging biomarkers for diagnosis and prediction of treatment responses in major depressive disorder

CH Lai - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
The neuroimaging is an important tool for understanding the biomarkers and predicting
treatment responses in major depressive disorder (MDD). The potential biomarkers and …

Brain‐Targeted Black Phosphorus‐Based Nanotherapeutic Platform for Enhanced Hypericin Delivery in Depression

H Tan, K Cao, Y Zhao, J Zhong, D Deng, B Pan… - Small, 2024 - Wiley Online Library
Depression is a significant global health concern that remains inadequately treated due to
the limited effectiveness of conventional drug therapies. One potential therapeutic agent …

Altered neurometabolite levels in the brains of patients with depression: A systematic analysis of magnetic resonance spectroscopy studies

X Xie, Y Shi, L Ma, W Yang, J Pu, Y Shen, Y Liu… - Journal of Affective …, 2023 - Elsevier
Background Numerous magnetic resonance spectroscopy (MRS) studies have reported
metabolic abnormalities in the brains of patients with depression, although inconsistent …