Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

MT Makale, CR McDonald… - Nature Reviews …, 2017 - nature.com
Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

Microglia in cancer therapy-related cognitive impairment

EM Gibson, M Monje - Trends in neurosciences, 2021 - cell.com
Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus

M Lambrecht, DBP Eekers, C Alapetite… - Radiotherapy and …, 2018 - Elsevier
Purpose For unbiased comparison of different radiation modalities and techniques,
consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose …

Regional susceptibility to dose-dependent white matter damage after brain radiotherapy

M Connor, R Karunamuni, C McDonald… - Radiotherapy and …, 2017 - Elsevier
Background and purpose Regional differences in sensitivity to white matter damage after
brain radiotherapy (RT) are not well-described. We characterized the spatial heterogeneity …

[HTML][HTML] Clinical applications of magnetic resonance imaging based functional and structural connectivity

C Wu, F Ferreira, M Fox, N Harel, J Hattangadi-Gluth… - Neuroimage, 2021 - Elsevier
Advances in computational neuroimaging techniques have expanded the armamentarium of
imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in …

Treatment of radiation‐induced brain necrosis

X Yang, H Ren, J Fu - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Radiation‐induced brain necrosis (RBN) is a serious complication of intracranial as well as
skull base tumors after radiotherapy. In the past, due to the lack of effective treatment …

Improved neuropsychological outcomes following proton therapy relative to X-ray therapy for pediatric brain tumor patients

JP Gross, S Powell, F Zelko, W Hartsell… - Neuro …, 2019 - academic.oup.com
Background Survivors of pediatric brain tumors are at risk for impaired development in
multiple neuropsychological domains. The purpose of this study was to compare …

Advanced magnetic resonance imaging techniques in management of brain metastases

H Mehrabian, J Detsky, H Soliman, A Sahgal… - Frontiers in …, 2019 - frontiersin.org
Brain metastases are the most common intracranial tumors and occur in 20–40% of all
cancer patients. Lung cancer, breast cancer, and melanoma are the most frequent primary …

Regional responses in radiation-induced normal tissue damage

DC Voshart, J Wiedemann, P van Luijk, L Barazzuol - Cancers, 2021 - mdpi.com
Simple Summary Side effects caused by the concomitant irradiation of normal tissue during
radiotherapy for cancer treatment can negatively affect the patient's quality of life and limit …

Cognitive impairment and morphological changes after radiation therapy in brain tumors: a review

J Jacob, T Durand, L Feuvret, JJ Mazeron… - Radiotherapy and …, 2018 - Elsevier
Life expectancy of patients treated for brain tumors has lengthened due to the therapeutic
improvements. Cognitive impairment has been described following brain radiotherapy, but …