E-cadherin is a key component of the adherens junctions that are integral in cell adhesion
and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells …

β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

Embryogenesis is directed by morphogens that induce differentiation within a defined tissue
geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) …

The epithelial–mesenchymal transition is essential in both embryonic development and the
progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been …

Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of
diagnosis. The mechanisms that confer this rapid metastatic capacity to lung tumors are …

Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …

Classical cadherins mediate specific adhesion at intercellular adherens junctions.
Interactions between cadherin ectodomains from apposed cells mediate cell–cell contact …

Controlled regulation of cell proliferation and differentiation is essential for embryonic
development and requires the coordinated regulation of cell–cell adhesion and gene …

Scientists have tried for decades to understand cancer development in the context of
therapeutic strategies. The realization that cancers may rely on “cancer stem cells” that …

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover
heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition …