Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Chalcones belong to the flavonoid class of phenolic compounds. They form one of the
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …

Among a group of 310 natural antiviral natural metabolites, our team identified three
compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease …

Drug repurposing is an unconventional drug discovery approach to explore new therapeutic
benefits of existing, shelved and the drugs in clinical trials. This approach is currently …

COVID-19 and its causative organism SARS-CoV2 that emerged from Wuhan city, China
have paralyzed the world. With no clinically approved drugs, the global health system is …

Identification of endocrine-disrupting chemicals (EDCs) is crucial in the reduction of human
health risks. However, it is hard to do so because of the complex mechanisms of the EDCs …

Breast cancer (BCa) is one of the most predominantly diagnosed cancers in women.
Notably, 70% of BCa diagnoses are Estrogen Receptor α positive (ERα+) making it a critical …

A new dicoumarin, jusan coumarin,(1), has been isolated from Artemisia glauca aerial parts.
The chemical structure of jusan coumarin was estimated, by 1D, 2D NMR as well as HR-Ms …

The physiological responses to estrogen hormones are mediated within specific tissues by
at least two distinct receptors, ERα and ERβ. Several natural and synthetic molecules show …