Recent quality by design approaches for process optimization and quality enhancement of dry powder inhalers
JH Jeong, JH Choi, JH Yoo, YR Choi, JH Kang… - Journal of …, 2024 - Springer
Abstract Background Dry powder inhalers (DPIs) are a widely used method for delivering
drugs directly to the lungs, where particle size and design critically influence inhalation …
drugs directly to the lungs, where particle size and design critically influence inhalation …
ZnO Nanoparticles of Rubia cordifolia Extract Formulation Developed and Optimized with QbD Application, Considering Ex Vivo Skin Permeation, Antimicrobial and …
The objective of the current research is to develop ZnO-Manjistha extract (ZnO-MJE)
nanoparticles (NPs) and to investigate their transdermal delivery as well as antimicrobial …
nanoparticles (NPs) and to investigate their transdermal delivery as well as antimicrobial …
Fabrication of Biodegradable Superabsorbent Using RSM Design for Controlled Release of KNO3
Present study envisaged the sequential experimental design approach for the development
of biodegradable Gelatin-Tapoica/polyacrylamide superabsorbent. Percentage water uptake …
of biodegradable Gelatin-Tapoica/polyacrylamide superabsorbent. Percentage water uptake …
Novel extended IVIVC combined with DoE to predict pharmacokinetics from formulation compositions
The objective of this study was to develop a novel extended in vitro in vivo correlation
(IVIVC) model combined with design of experiment (DoE) that integrates the DoE into IVIVC …
(IVIVC) model combined with design of experiment (DoE) that integrates the DoE into IVIVC …
[HTML][HTML] A validated high-performance liquid chromatography-ultraviolet method for the determination of valproic acid derivatives in pharmaceutical formulations with a …
AH Alluhayb, MF Al-Hakkani, M Abdulnasser… - Talanta Open, 2024 - Elsevier
Valproic acid and its derivatives are common drugs used in the treatment of epilepsy, a
result of CNS disorders. Because the molecular structure of valproic acid, as a fatty acid …
result of CNS disorders. Because the molecular structure of valproic acid, as a fatty acid …
[HTML][HTML] Analytical investigation of the possible chemical interaction of methyldopa with some reducing carbohydrates used as pharmaceutical excipients
MR Siahi, S Rahimi… - Advanced Pharmaceutical …, 2018 - ncbi.nlm.nih.gov
Purpose: Assessment of drug substance and excipients compatibility is an important issue
during pre-formulation studies as well as the quality control of pharmaceutical dosage forms …
during pre-formulation studies as well as the quality control of pharmaceutical dosage forms …
Application of quality by design approach to optimize process and formulation parameters of rizatriptan loaded chitosan nanoparticles
AE Shirsat, SS Chitlange - Journal of advanced pharmaceutical …, 2015 - journals.lww.com
The purpose of present study was to optimize rizatriptan (RZT) chitosan (CS) nanoparticles
using ionic gelation method by application of quality by design (QbD) approach. Based on …
using ionic gelation method by application of quality by design (QbD) approach. Based on …
Fabrication of extended-dissolution divalproex tablets: a green solvent-free granulation technique
A Khaled, S Abdel-Hamid, M Nasr… - Drug Development and …, 2020 - Taylor & Francis
Objective: Divalproex sodium (DVS) is a challenging drug owing to its hygroscopicity, bitter
taste, and short in vivo half-life. This study aims to produce stable taste masked DVS once …
taste, and short in vivo half-life. This study aims to produce stable taste masked DVS once …
Investigation of possible maillard reaction between acyclovir and dextrose upon dilution prior to parenteral administration
MR Siahi Shadbad, F Ghaderi, L Hatami… - AAPS …, 2016 - Springer
In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as
large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard …
large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard …
Vibrational spectral and electronic properties, Topology studies and biological assay of a potent Anticonvulsant agent: Divalproex Sodium
B Amul, S Sakthivel, R Rajesh, S Kadaikunnan… - Spectroscopy …, 2023 - Taylor & Francis
In this research work, Density Functional Theory based computational analysis on the
molecular structure of Divalproex Sodium was carried out in the gas phase. Comprehensive …
molecular structure of Divalproex Sodium was carried out in the gas phase. Comprehensive …