Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …

Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …

Coronary plaque rupture is the most common cause of vessel thrombosis and acute
coronary syndrome. The accurate early detection of plaques prone to rupture may allow …

Elastic and collagen fibers are well known to be the major load-bearing extracellular matrix
(ECM) components of the arterial wall. Studies of the structural components and mechanics …

Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

The primary function of central arteries is to store elastic energy during systole and to use it
to sustain blood flow during diastole. Arterial stiffening compromises this normal mechanical …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Tissue-level biomechanical properties and function derive from underlying cell signaling,
which regulates mass deposition, organization, and removal. Here, we couple two existing …