Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …

Humans obtain most of their vitamin D through the exposure of skin to sunlight. The
immunoregulatory properties of vitamin D have been demonstrated in studies showing that …

The human skin is an integral system that acts as a physical and immunological barrier to
outside pathogens, toxicants, and harmful irradiations. Environmental ultraviolet rays (UV) …

UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …

No one would underestimate the importance of sunlight to the evolution of life on the earth
and its role in human development. However, all humans–especially individuals who are …

Over the past several decades, there has been increasing interest in understanding the
roles of the immune system in the development and progression of cancer. The importance …

Unmitigated UV radiation (UVR) induces skin photoaging and multiple forms of cutaneous
carcinoma by complex pathways that include those mediated by UV-induced reactive …

Actinic keratoses are proliferations of transformed neoplastic keratinocytes in the epidermis
that are the result of cumulative ultraviolet (UV) radiation from sun exposure. They are …

The realisation that UV radiation (UVR) exposure could induce a suppressed immune
environment for the initiation of carcinogenesis in the skin was first described more than 40 …

Nicotinamide (vitamin B3) protects from ultraviolet (UV) radiation-induced carcinogenesis in
mice and from UV-induced immunosuppression in mice and humans. Recent double …