[HTML][HTML] Mitochondrial control of inflammation
Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …
associated molecular patterns (DAMPs) and promote inflammation when released into the …
Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …
This system comprises an array of sensors that, after detecting viral molecules, activate the …
[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism
V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
[HTML][HTML] Designing spatial and temporal control of vaccine responses
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …
However, increasing the potency, quality and durability of the vaccine response remains a …
[HTML][HTML] Role of the cGAS–STING pathway in systemic and organ-specific diseases
S Skopelja-Gardner, J An, KB Elkon - Nature Reviews Nephrology, 2022 - nature.com
Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
The induction of type I interferons through the transcription factor interferon regulatory factor
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
Molecular mechanisms and cellular functions of cGAS–STING signalling
KP Hopfner, V Hornung - Nature reviews Molecular cell biology, 2020 - nature.com
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
[HTML][HTML] Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
Turning cold into hot: firing up the tumor microenvironment
Cancers develop within complex tissue environments consisting of diverse innate and
adaptive immune cells, along with stromal cells, vascular networks, and many other cellular …
adaptive immune cells, along with stromal cells, vascular networks, and many other cellular …
[HTML][HTML] eccDNAs are apoptotic products with high innate immunostimulatory activity
Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature
for several decades, and are known for their broad existence across different species …
for several decades, and are known for their broad existence across different species …