A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

Little is known about the genetic changes that distinguish domestic cat populations from
their wild progenitors. Here we describe a high-quality domestic cat reference genome …

Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for
neural development, and brain cells frequently contain somatic genomic variations that …

More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with
autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 …

Abstract Background Recent Genome Wide Association Studies (GWAS) have identified
novel rare coding variants in immune genes associated with late onset Alzheimer's disease …

Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional
Amerindian medicine recently associated with cognitive gains, antidepressant effects, and …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Neurotrophic factors are essential not only for guiding the organization of the developing
nervous system but also for supporting the survival and growth of neurons after traumatic …