Molecular targets for components of essential oils in the insect nervous system—a review

M Jankowska, J Rogalska, J Wyszkowska… - Molecules, 2017 - mdpi.com
Essential oils (EOs) are lipophilic secondary metabolites obtained from plants; terpenoids
represent the main components of them. A lot of studies showed neurotoxic actions of EOs …

Broflanilide: A meta-diamide insecticide with a novel mode of action

T Nakao, S Banba - Bioorganic & medicinal chemistry, 2016 - Elsevier
Broflanilide is a meta-diamide [3-benzamido-N-(4-(perfluoropropan-2-yl) phenyl)
benzamide] that exhibits high larvicidal activity against Spodoptera litura. It has been …

Chemoconnectomics: mapping chemical transmission in Drosophila

B Deng, Q Li, X Liu, Y Cao, B Li, Y Qian, R Xu, R Mao… - Neuron, 2019 - cell.com
We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …

A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

SD Schoville, YH Chen, MN Andersson, JB Benoit… - Scientific reports, 2018 - nature.com
The Colorado potato beetle is one of the most challenging agricultural pests to manage. It
has shown a spectacular ability to adapt to a variety of solanaceaeous plants and variable …

Convergent resistance to GABA receptor neurotoxins through plant–insect coevolution

L Guo, X Qiao, D Haji, T Zhou, Z Liu… - Nature Ecology & …, 2023 - nature.com
The molecular mechanisms of coevolution between plants and insects remain elusive.
GABA receptors are targets of many neurotoxic terpenoids, which represent the most diverse …

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo‐oligomeric GABA receptor from Drosophila …

CM Priestley, EM Williamson… - British journal of …, 2003 - Wiley Online Library
The GABA‐modulating and GABA‐mimetic activities of the monoterpenoid thymol were
explored on human GABAA and Drosophila melanogaster homomeric RDLac GABA …

The GABAergic nervous system of Caenorhabditis elegans

SL Mclntire, E Jorgensen, J Kaplan, HR Horvitz - Nature, 1993 - nature.com
Abstract γ-AMINOBUTYRIC acid (GABA) is the most abundant inhibitory neurotransmitter in
vertebrates and invertebrates1. GABA receptors are the target of anxiolytic, antiepileptic and …

A point mutation in a Drosophila GABA receptor confers insecticide resistance

RH Ffrench-Constant, TA Rocheleau, JC Steichen… - Nature, 1993 - nature.com
VERTEBRATES and invertebrates both have GABA (γ-aminobutyric acid) as a major
inhibitory neurotransmitter1, 2. GABAA receptors in vertebrates assemble as …

Molecular mechanisms of insecticide resistance

DM Soderlund, JR Bloomquist - Pesticide resistance in arthropods, 1990 - Springer
Four decades of intensive use of synthetic organic insecticides to control arthropod pests
and disease vectors have led to the selection of insecticide or acaricide resistance in …

Decreased expression of the GABAA receptor in fragile X syndrome

C d'Hulst, N De Geest, SP Reeve, D Van Dam… - Brain research, 2006 - Elsevier
After our initial discovery of under expression of the GABAA receptor δ subunit in a genome
wide screening for differentially expressed mRNAs in brain of fragile X mice, a validated …