Synovial fluid concentrations and relative potency of interleukin‐1 alpha and beta in cartilage and meniscus degradation

AL McNulty, NE Rothfusz, HA Leddy… - Journal of Orthopaedic …, 2013 - Wiley Online Library
Cartilage degeneration with osteoarthritis (OA) is believed to involve the activities of
interleukin‐1 (IL‐1), which exists as alpha and beta isoforms. The goal of this study was to …

Developing an articular cartilage decellularization process toward facet joint cartilage replacement

BD Elder, DH Kim, KA Athanasiou - Neurosurgery, 2010 - journals.lww.com
OBJECTIVE: The facet joint has been identified as a significant source of morbidity in lower
back pain. In general, treatments have focused on reducing the pain associated with facet …

Stress-relaxation response of human menisci under confined compression conditions

AM Seitz, F Galbusera, C Krais, A Ignatius… - Journal of the …, 2013 - Elsevier
The objective of this study was to determine the viscoelastic properties of human meniscal
tissue during stress-relaxation under confined compression conditions. Lateral and medial …

[HTML][HTML] Advanced glycation end-products and bone fractures

D Vashishth - Ibms Bonekey, 2009 - ncbi.nlm.nih.gov
Bone does not turn over uniformly, and becomes susceptible to post-translational
modification by non-enzymatic glycation (NEG). NEG of bone causes the formation of …

Constitutive modeling of cartilaginous tissues: a review

ZA Taylor, K Miller - Journal of applied biomechanics, 2006 - journals.humankinetics.com
An important and longstanding field of research in orthopedic biomechanics is the
elucidation and mathematical modeling of the mechanical response of cartilaginous tissues …

Effect of glutaraldehyde fixation on the frictional response of immature bovine articular cartilage explants

SR Oungoulian, KE Hehir, K Zhu, CE Willis… - Journal of …, 2014 - Elsevier
This study examined functional properties and biocompatibility of glutaraldehyde-fixed
bovine articular cartilage over several weeks of incubation at body temperature to …

Tissue crosslinking for treatment of snoring and obstructive sleep apnea

TP Hedman, P Slusarewicz - US Patent 9,192,507, 2015 - Google Patents
6,375,672 B1 4/2002 Aksan et al. 6,439,238 B1 8, 2002 Brenzel et al. 6,726,920 B1 4/2004
Theeuwes et al. 6,812,211 B2 11/2004 Slivka et al. 7,435,722 B2 10/2008 Hedman of the …

The effects of exogenous crosslinking on hydration and fluid flow in the intervertebral disc subjected to compressive creep loading and unloading

SY Chuang, JM Popovich Jr, LC Lin, TP Hedman - Spine, 2010 - journals.lww.com
Study Design. In vitro study of genipin crosslinking effect on disc water content changes
under compressive loading and unloading. Objective. To investigate the influence of …

Genipin crosslinker releasing sutures for improving the mechanical/repair strength of damaged connective tissue

S Sundararaj, P Slusarewicz, M Brown… - Journal of Biomedical …, 2017 - Wiley Online Library
The most common mode of surgical repair of ruptured tendons and ligaments involves the
use of sutures for reattachment. However, there is a high incidence of rerupture and repair …

Beneficial effects of exogenous crosslinking agents on self-assembled tissue engineered cartilage construct biomechanical properties

BD Elder, A Mohan, KA Athanasiou - Journal of Mechanics in …, 2011 - World Scientific
Background. As articular cartilage is unable to repair itself, there is a tremendous clinical
need for a tissue engineered replacement tissue. Current tissue engineering efforts using …