Three sentinel parameters of aerobic performance are the maximal oxygen uptake (), critical
power (CP) and speed of the kinetics following exercise onset. Of these, the latter is …

Approximately half of patients with heart failure have preserved ejection fraction. There is no
proven treatment that improves outcome. The pathophysiology of heart failure with …

Rationale: Nitrate-rich beetroot juice has been shown to improve exercise capacity in heart
failure with preserved ejection fraction, but studies using pharmacological preparations of …

We hypothesized that 4 wk of dietary nitrate supplementation would enhance exercise
performance and muscle metabolic adaptations to sprint interval training (SIT). Thirty-six …

Multiple phase III trials over the last few decades have failed to demonstrate a clear benefit
of various pharmacologic interventions in heart failure with a preserved left ventricular (LV) …

This review strikes at the very heart of how the microcirculation functions to facilitate blood-
tissue oxygen, substrate, and metabolite fluxes in skeletal muscle. Contemporary evidence …

Chronic kidney disease (CKD) manifests with systemic inflammation, oxidative stress, and
gut dysbiosis, resulting in metabolic disorders and elevated rates of cardiovascular disease …

Key points Within skeletal muscle the greatest resistance to oxygen transport is thought to
reside across the short distance at the red blood cell–myocyte interface. These structures …

Objective To determine whether nitrite can enhance exercise training (ET) effects in heart
failure with preserved ejection fraction (HFpEF). Methods In this multicenter, double-blind …

Key points Oral sulphonylureas, widely prescribed for diabetes, inhibit pancreatic ATP‐
sensitive K+ (KATP) channels to increase insulin release. However, KATP channels are also …