Cellular senescence: the good, the bad and the unknown
W Huang, LTJ Hickson, A Eirin, JL Kirkland… - Nature Reviews …, 2022 - nature.com
Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …
Oxidative stress and redox regulation on in vitro development of mammalian embryos
M Takahashi - Journal of Reproduction and Development, 2012 - jstage.jst.go.jp
Many factors affect development of mammalian preimplantation embryos in vitro. It is well
known that in vitro development of bovine embryos is highly affected by culture condition …
known that in vitro development of bovine embryos is highly affected by culture condition …
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …
found in the elderly population, and several studies have demonstrated that aging is the …
Mitochondrial function and redox state in mammalian embryos
Mitochondria play a central and multifaceted role in the mammalian egg and early embryo,
contributing to many different aspects of early development. While the contribution of …
contributing to many different aspects of early development. While the contribution of …
Permanent embryo arrest: molecular and cellular concepts
Developmental arrest is one of the mechanisms responsible for the elevated levels of
embryo demise during the first week of in vitro development. Approximately 10–15% of IVF …
embryo demise during the first week of in vitro development. Approximately 10–15% of IVF …
Genetic divergence in cellular resistance to heat shock in cattle: differences between breeds developed in temperate versus hot climates in responses of …
FF Paula-Lopes, CC Chase, YM Al-Katanani… - …, 2003 - rep.bioscientifica.com
The detrimental effects of heat stress on fertility in cattle are less pronounced in heat-tolerant
breeds. Although these genetic differences reflect differences in thermoregulation, cells from …
breeds. Although these genetic differences reflect differences in thermoregulation, cells from …
p66Shc in cardiovascular pathology
L Haslem, JM Hays, FA Hays - Cells, 2022 - mdpi.com
p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies
by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc's …
by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc's …
Senescence and Apoptosis During in vitro Embryo Development in a Bovine Model
P Ramos-Ibeas, I Gimeno, K Cañón-Beltrán… - Frontiers in cell and …, 2020 - frontiersin.org
According to the World Health Organization, infertility affects up to 14% of couples under
reproductive age, leading to an exponential rise in the use of assisted reproduction as a …
reproductive age, leading to an exponential rise in the use of assisted reproduction as a …
NLRP5 mediates mitochondrial function in mouse oocytes and embryos
R Fernandes, C Tsuda, AL Perumalsamy… - Biology of …, 2012 - academic.oup.com
Unraveling molecular pathways responsible for regulation of early embryonic development
is crucial for our understanding of female infertility. Maternal determinants that control the …
is crucial for our understanding of female infertility. Maternal determinants that control the …
TEAD4 establishes the energy homeostasis essential for blastocoel formation
KJ Kaneko, ML DePamphilis - Development, 2013 - journals.biologists.com
It has been suggested that during mouse preimplantation development, the zygotically
expressed transcription factor TEAD4 is essential for specification of the trophectoderm …
expressed transcription factor TEAD4 is essential for specification of the trophectoderm …