Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Many factors affect development of mammalian preimplantation embryos in vitro. It is well
known that in vitro development of bovine embryos is highly affected by culture condition …

Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …

Mitochondria play a central and multifaceted role in the mammalian egg and early embryo,
contributing to many different aspects of early development. While the contribution of …

Developmental arrest is one of the mechanisms responsible for the elevated levels of
embryo demise during the first week of in vitro development. Approximately 10–15% of IVF …

The detrimental effects of heat stress on fertility in cattle are less pronounced in heat-tolerant
breeds. Although these genetic differences reflect differences in thermoregulation, cells from …

p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies
by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc's …

According to the World Health Organization, infertility affects up to 14% of couples under
reproductive age, leading to an exponential rise in the use of assisted reproduction as a …

Unraveling molecular pathways responsible for regulation of early embryonic development
is crucial for our understanding of female infertility. Maternal determinants that control the …

It has been suggested that during mouse preimplantation development, the zygotically
expressed transcription factor TEAD4 is essential for specification of the trophectoderm …