In the last 25 years, 13 C MRS has been established as the only noninvasive method for the
measurement of glutamate neurotransmission and cell‐specific neuroenergetics. Although …

Hyperpolarized magnetic resonance allows for noninvasive measurements of biochemical
reactions in vivo. Although this technique provides a unique tool for assaying enzymatic …

This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]
pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for …

Abstract Hyperpolarized (HP) 13 C Magnetic Resonance Imaging (MRI) was applied for the
first time to image and quantify the uptake and metabolism of [2–13 C] pyruvate in the …

Gain-of-function mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the
most prevalent in low-grade gliomas and secondary glioblastoma. They lead to intracellular …

The Krebs tricarboxylic acid cycle (TCA) is central to metabolic energy production and is
known to be altered in many disease states. Real-time molecular imaging of the TCA cycle …

Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging
Clinical Applications is the first comprehensive book for non-physicists that addresses the …

Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been
proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure …

This article describes the basic physics of dissolution dynamic nuclear polarization
(dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the …

The activity of specific enzyme‐catalyzed reactions may be detected in vivo by 13 C NMR of
hyperpolarized (HP) substrates. The signals from HP substrates and products, acquired over …