Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers
through methylation and molecular rearrangement. These functions take place in fatty acid …

Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

Background Remethylation defects are rare inherited disorders in which impaired
remethylation of homocysteine to methionine leads to accumulation of homocysteine and …

Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A
genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the …

Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

The lysosomal membrane was thought for a long time to primarily act as a physical barrier
separating the luminal acidic milieu from the cytoplasmic environment. Meanwhile, it has …

Vitamin B12, also known as the anti-pernicious anemia factor, is an essential micronutrient
totally dependent on dietary sources that is commonly integrated with food supplements …

Inherited disorders of vitamin B12 (cobalamin) have provided important clues to how this
vitamin, which is essential for hematological and neurological function, is transported and …