Prenatal testing in recent years has been moving toward non-invasive methods to determine
the fetal risk for genetic disorders without incurring the risk of miscarriage. Rapid progress of …

Introduction Globally, preterm birth has replaced congenital malformation as the major
cause of perinatal mortality and morbidity. The reduced rate of congenital malformation was …

Determining if specific cell type (s) are responsible for an association between DNA
methylation (DNAm) and a given phenotype is important for understanding the biological …

Objectives We aimed to compare cell‐based NIPT (cbNIPT) to chorionic villus sampling
(CVS) and to examine the test characteristics of cbNIPT in the first clinical validation study of …

Clinically, unique markers in fetal membrane cells may contribute to the search for
biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood …

Being easy, safe and reliable, non-invasive prenatal diagnosis (NIPD) has been greatly
pursued in recent years. Holding the complete genetic information of the fetus, fetal …

Fetal nucleated red blood cells (fNRBC) in maternal peripheral blood has the potential for
non-invasive prenatal diagnostics (NIPD), given its intrinsic nature carrying total genetic …

Monogenic inherited diseases are common causes of congenital disabilities, leading to
severe economic and mental burdens on affected families. In our previous study, we …

In recent years, viscoelastic particle manipulation within microfluidic systems has received
much attention due to the ease with which micron-sized objects may be maneuvered and …

Several miRNAs are expressed in human gestational tissue, and some have been shown to
be associated with placental dysfunction and complicated pregnancy outcomes. To …