Scorpion venom: detriments and benefits

S Ahmadi, JM Knerr, L Argemi, KCF Bordon, MB Pucca… - Biomedicines, 2020 - mdpi.com
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …

Tityus serrulatus venom–a lethal cocktail

MB Pucca, FA Cerni, ELP Junior, KCF Bordon… - Toxicon, 2015 - Elsevier
Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom
is composed of several compounds such as mucus, inorganic salts, lipids, amines …

[HTML][HTML] Effects of Brazilian scorpion venoms on the central nervous system

ALA Nencioni, E Beraldo Neto, LA Freitas… - Journal of venomous …, 2018 - SciELO Brasil
In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus
genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are …

[HTML][HTML] An overview of Tityus cisandinus scorpion venom: Transcriptome and mass fingerprinting reveal conserved toxin homologs across the Amazon region and …

Y Kalapothakis, K Miranda, DAM Molina… - International Journal of …, 2023 - Elsevier
Tityus cisandinus, a neglected medically important scorpion in Ecuadorian and Peruvian
Amazonia, belongs to a complex of species related to the eastern Amazon endemic Tityus …

Scorpion toxin peptide action at the ion channel subunit level

DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …

[HTML][HTML] Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom

ME Lodovicho, TR Costa, CP Bernardes, DL Menaldo… - Toxicology letters, 2017 - Elsevier
Cysteine-rich secretory proteins (CRISPs) are commonly described as part of the protein
content of snake venoms, nevertheless, so far, little is known about their biological targets …

The nociceptive response induced by different classes of Tityus serrulatus neurotoxins: The important role of Ts5 in venom-induced nociception

F Cerni, I Oliveira, F Cordeiro, K Bordon… - PLOS Neglected …, 2023 - journals.plos.org
Scorpion sting envenomations (SSE) are feared by the intense pain that they produce in
victims. Pain from SSE is triggered mainly by the presence of neurotoxins in the scorpion …

[HTML][HTML] Novel components of Tityus serrulatus venom: A transcriptomic approach

Y Kalapothakis, K Miranda, AH Pereira, ASA Witt… - Toxicon, 2021 - Elsevier
Several research groups have studied the components produced by the venom gland of the
scorpion Tityus serrulatus, which has one of the most lethal venoms in the world. Various …

Beta-KTx14. 3, a scorpion toxin, blocks the human potassium channel KCNQ1

G Titaux-Delgado, AE Lopez-Giraldo, E Carrillo… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Potassium channels play a key role in regulating many physiological processes, thus,
alterations in their proper functioning can lead to the development of several diseases …

[HTML][HTML] Ts8 scorpion toxin inhibits the Kv4. 2 channel and produces nociception in vivo

MB Pucca, FA Cerni, FA Cordeiro, S Peigneur… - Toxicon, 2016 - Elsevier
The venom from the scorpion Tityus serrulatus (Ts) has been extensively studied mainly
because of its rich cocktail of neurotoxins. Neurotoxins are the major and the most known …