Plasmonics is the discipline that investigates the use of collective oscillations of conductive
electrons in metallic nanostructures, called surface plasmons (SPs), to realize a large set of …

Many light-based technologies have been developed to manipulate micro/nanoscale
objects such as colloidal particles and biological cells for basic research and practical …

Optical tweezers use the momentum carried by light to exert forces on objects. They have
had a profound impact on a truly diverse range of scientific fields, from biology to …

Single molecule analysis of proteins in an aqueous environment without modification (eg,
labels or tethers) elucidates their biophysics and interactions relevant to drug discovery. By …

Optical trapping with nanostructured metals has allowed for label-free tether-free analysis of
single proteins (and other biomolecules) and their interactions with detector-limited time …

Highlights•Studying biomolecular folding with optical tweezers grants high dynamic
range.•Combining optical tweezers with molecular dynamics simulation enables accurate …

Nanopores play essential roles in biological processes, such as ion channels and pumps in
cellular membranes, and in technological applications such as DNA sequencing …

The manipulation of molecules placed in close proximity to a liquid is crucial for
understanding their interactions, as in the study of antibiotics against bacteria. This can, in …

PR65 is the HEAT repeat scaffold subunit of the heterotrimeric protein phosphatase 2A
(PP2A) and an archetypal tandem repeat protein. Its conformational mechanics plays a …

Zero-mode waveguide (ZMW) nanoapertures are widely used to monitor single molecules
beyond the range accessible to normal microscopes. However, several aspects of the ZMW …