Syntax-guided optimal synthesis for chemical reaction networks
We study the problem of optimal syntax-guided synthesis of stochastic Chemical Reaction
Networks (CRNs) that plays a fundamental role in design automation of molecular devices …
Networks (CRNs) that plays a fundamental role in design automation of molecular devices …
A genetically modified Hoare logic
G Bernot, JP Comet, Z Khalis, A Richard… - Theoretical Computer …, 2019 - Elsevier
An important problem when modelling gene networks lies in the identification of parameters,
even when using a discrete framework such as the one of René Thomas. We present in this …
even when using a discrete framework such as the one of René Thomas. We present in this …
Formal analysis of qualitative long-term behaviour in parametrised boolean networks
Boolean networks offer an elegant way to model the behaviour of complex systems with
positive and negative feedback. The long-term behaviour of a Boolean network is …
positive and negative feedback. The long-term behaviour of a Boolean network is …
Parallel SMT-based parameter synthesis with application to piecewise multi-affine systems
We propose a novel scalable parallel algorithm for synthesis of interdependent parameters
from CTL specifications for non-linear dynamical systems. The method employs a symbolic …
from CTL specifications for non-linear dynamical systems. The method employs a symbolic …
Semi-quantitative abstraction and analysis of chemical reaction networks
M Češka, J Křetínský - … : 31st International Conference, CAV 2019, New …, 2019 - Springer
Abstract Analysis of large continuous-time stochastic systems is a computationally intensive
task. In this work we focus on population models arising from chemical reaction networks …
task. In this work we focus on population models arising from chemical reaction networks …
CRNs exposed: Systematic exploration of chemical reaction networks
Formal methods have enabled breakthroughs in many fields, such as in hardware
verification, machine learning and biological systems. The key object of interest in systems …
verification, machine learning and biological systems. The key object of interest in systems …
Model checking gene regulatory networks
The behaviour of gene regulatory networks (GRNs) is typically analysed using simulation-
based statistical testing-like methods. In this paper, we demonstrate that we can replace this …
based statistical testing-like methods. In this paper, we demonstrate that we can replace this …
Model checking the evolution of gene regulatory networks
The behaviour of gene regulatory networks (GRNs) is typically analysed using simulation-
based statistical testing-like methods. In this paper, we demonstrate that we can replace this …
based statistical testing-like methods. In this paper, we demonstrate that we can replace this …
Discovering vesicle traffic network constraints by model checking
A eukaryotic cell contains multiple membrane-bound compartments. Transport vesicles
move cargo between these compartments, just as trucks move cargo between warehouses …
move cargo between these compartments, just as trucks move cargo between warehouses …
[HTML][HTML] Parallel parameter synthesis algorithm for hybrid CTL
Parametrised models of dynamical systems arise in various areas of science. In this work,
we focus on models described as parametrised Kripke structures with properties formulated …
we focus on models described as parametrised Kripke structures with properties formulated …