Syntax-guided optimal synthesis for chemical reaction networks

L Cardelli, M Češka, M Fränzle, M Kwiatkowska… - … Aided Verification: 29th …, 2017 - Springer
We study the problem of optimal syntax-guided synthesis of stochastic Chemical Reaction
Networks (CRNs) that plays a fundamental role in design automation of molecular devices …

A genetically modified Hoare logic

G Bernot, JP Comet, Z Khalis, A Richard… - Theoretical Computer …, 2019 - Elsevier
An important problem when modelling gene networks lies in the identification of parameters,
even when using a discrete framework such as the one of René Thomas. We present in this …

Formal analysis of qualitative long-term behaviour in parametrised boolean networks

N Beneš, L Brim, S Pastva, J Poláček… - Formal Methods and …, 2019 - Springer
Boolean networks offer an elegant way to model the behaviour of complex systems with
positive and negative feedback. The long-term behaviour of a Boolean network is …

Parallel SMT-based parameter synthesis with application to piecewise multi-affine systems

N Beneš, L Brim, M Demko, S Pastva… - Automated Technology for …, 2016 - Springer
We propose a novel scalable parallel algorithm for synthesis of interdependent parameters
from CTL specifications for non-linear dynamical systems. The method employs a symbolic …

Semi-quantitative abstraction and analysis of chemical reaction networks

M Češka, J Křetínský - … : 31st International Conference, CAV 2019, New …, 2019 - Springer
Abstract Analysis of large continuous-time stochastic systems is a computationally intensive
task. In this work we focus on population models arising from chemical reaction networks …

CRNs exposed: Systematic exploration of chemical reaction networks

M Vasic, D Soloveichik, S Khurshid - arXiv preprint arXiv:1912.06197, 2019 - arxiv.org
Formal methods have enabled breakthroughs in many fields, such as in hardware
verification, machine learning and biological systems. The key object of interest in systems …

Model checking gene regulatory networks

M Giacobbe, CC Guet, A Gupta, TA Henzinger… - … Conference on Tools …, 2015 - Springer
The behaviour of gene regulatory networks (GRNs) is typically analysed using simulation-
based statistical testing-like methods. In this paper, we demonstrate that we can replace this …

Model checking the evolution of gene regulatory networks

M Giacobbe, CC Guet, A Gupta, TA Henzinger… - Acta Informatica, 2017 - Springer
The behaviour of gene regulatory networks (GRNs) is typically analysed using simulation-
based statistical testing-like methods. In this paper, we demonstrate that we can replace this …

Discovering vesicle traffic network constraints by model checking

A Shukla, A Bhattacharyya, L Kuppusamy, M Srivas… - PloS one, 2017 - journals.plos.org
A eukaryotic cell contains multiple membrane-bound compartments. Transport vesicles
move cargo between these compartments, just as trucks move cargo between warehouses …

[HTML][HTML] Parallel parameter synthesis algorithm for hybrid CTL

N Beneš, L Brim, S Pastva, D Šafránek - Science of Computer …, 2020 - Elsevier
Parametrised models of dynamical systems arise in various areas of science. In this work,
we focus on models described as parametrised Kripke structures with properties formulated …