Single-cell RNA sequencing in vision research: Insights into human retinal health and disease
Gene expression provides valuable insight into cell function. As such, vision researchers
have frequently employed gene expression studies to better understand retinal physiology …
have frequently employed gene expression studies to better understand retinal physiology …
The crosstalk between glomerular endothelial cells and podocytes controls their responses to metabolic stimuli in diabetic nephropathy
M Albrecht, C Sticht, T Wagner, SA Hettler… - Scientific Reports, 2023 - nature.com
In diabetic nephropathy (DN), glomerular endothelial cells (GECs) and podocytes undergo
pathological alterations, which are influenced by metabolic changes characteristic of …
pathological alterations, which are influenced by metabolic changes characteristic of …
Contribution of inhibitor of DNA binding/differentiation‐3 and endocrine disrupting chemicals to pathophysiological aspects of chronic disease
The overwhelming increase in the global incidence of obesity and its associated
complications such as insulin resistance, atherosclerosis, pulmonary disease, and …
complications such as insulin resistance, atherosclerosis, pulmonary disease, and …
Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system
J Jacobs-Li, W Tang, C Li, ME Bronner - Elife, 2023 - elifesciences.org
During development, much of the enteric nervous system (ENS) arises from the vagal neural
crest that emerges from the caudal hindbrain and colonizes the entire gastrointestinal tract …
crest that emerges from the caudal hindbrain and colonizes the entire gastrointestinal tract …
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension
MP Winter, S Sharma, J Altmann, V Seidl… - Basic Research in …, 2020 - Springer
Pulmonary arterial hypertension is a severe and progressive disease characterized by a
pulmonary vascular remodeling process with expansion of collateral endothelial cells and …
pulmonary vascular remodeling process with expansion of collateral endothelial cells and …
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype
The human choroidal vasculature is subject to age-related structural and gene expression
changes implicated in age-related macular degeneration (AMD). In this study, we performed …
changes implicated in age-related macular degeneration (AMD). In this study, we performed …
Brain infiltration of breast cancer stem cells is facilitated by paracrine signaling by inhibitor of differentiation 3 to nuclear respiratory factor 1
Abstract Treatment options for brain metastatic breast cancer are limited because the
molecular mechanism for how breast cancer cells infiltrate the brain is not fully understood …
molecular mechanism for how breast cancer cells infiltrate the brain is not fully understood …
Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells
Human blood vessel walls show concentric layers, with the outermost tunica adventitia
harboring mesenchymal progenitor cells. These progenitor cells maintain vessel …
harboring mesenchymal progenitor cells. These progenitor cells maintain vessel …
[HTML][HTML] Silibinin is a suppressor of the metastasis-promoting transcription factor ID3
S Verdura, JA Encinar, A Gratchev, À Llop-Hernández… - Phytomedicine, 2024 - Elsevier
Background ID3 (inhibitor of DNA binding/differentiation-3) is a transcription factor that
enables metastasis by promoting stem cell-like properties in endothelial and tumor cells …
enables metastasis by promoting stem cell-like properties in endothelial and tumor cells …
Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
S Okawa, C Saltó, S Ravichandran, S Yang… - Nature …, 2018 - nature.com
Single-cell RNA sequencing allows defining molecularly distinct cell subpopulations.
However, the identification of specific sets of transcription factors (TFs) that define the …
However, the identification of specific sets of transcription factors (TFs) that define the …