Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Adaptions to therapeutic pressures exerted on cancer cells enable malignant progression of
the tumor, culminating in escape from programmed cell death and development of resistant …

Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer
deaths in women. Here we present an integrated multi-omic analysis of 643 cervical …

Background Intrinsic or acquired resistance to epidermal growth factor receptor-tyrosine
kinase inhibitors (EGFR-TKIs) is common, thus strategies for the management of EGFR-TKIs …

Diffuse pleural mesothelioma (DPM) is a lethal cancer with a poor prognosis and limited
treatment options. The Hippo signaling pathway genes, such as NF2 and LATS1/2, are …

The adenosine pathway is an exciting new target in the field of cancer immunotherapy.
CD73 is the main producer of extracellular adenosine. Non-small cell lung cancer (NSCLC) …

Malignant pleural mesothelioma (MPM) is a lethal malignancy etiologically caused by
asbestos exposure, for which there are few effective treatment options. Although asbestos …

Malignant pleural mesothelioma is a rare and aggressive neoplasm, which has primarily
been attributed to the exposure to asbestos fibers (83% of cases); yet, despite a ban of using …

Simple Summary In the tumor microenvironment, interaction among tumor cells, immune
cells, stromal cells, and the extracellular matrix is vital to support pro-tumor mechanisms …

Abstract Neurofibromatosis type 2 (NF2) is a tumor suppressor gene implicated in various
tumors, including mesothelioma, schwannomas, and meningioma. As a member of the ezrin …