Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Proteins constitute the majority of nature's worker biomolecules. Designed for specific
functions, complex tertiary structures make proteins ideal candidates for analysing natural …

Protein-based conjugates are valuable constructs for a variety of applications. Conjugation
of proteins to fluorophores is commonly used to study their cellular localization and the …

Chemists, biologists, and material scientists alike have long sought to control protein
presentation, orientation, and activity within biomaterials to dictate reaction catalysis …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …

Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …

The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …

Many systemic cancer chemotherapies comprise a combination of drugs, yet all clinically
used antibody–drug conjugates (ADCs) contain a single-drug payload. These combination …

Protein prenylation is a post-translational modification that has been most commonly
associated with enabling protein trafficking to and interaction with cellular membranes. In …