The process of drug development is expensive and time-consuming. In contrast, drug
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …

According to the latest cancer research data, there are a significant number of new cancer
cases and a substantial mortality rate each year. Although a substantial number of clinical …

Plasma proteins are promising biomarkers and potential drug targets in lung cancer. To
evaluate the causal association between plasma proteins and lung cancer, we performed …

Background The causal associations of lipids and the drug target genes with atrial fibrillation
(AF) risk remain obscure. We aimed to investigate the causal associations using genetic …

Objective To identify susceptible biomarkers for the development of bipolar disorder (BD),
we conducted a Mendelian Randomization (MR) design to screen circulating proteins for the …

Background. The COVID‐19 pandemic caused by the SARS‐CoV‐2 virus has resulted in a
global health crisis with significant morbidity and mortality. While effective vaccinations have …

Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as
receptor activation or molecule transfer. Estimates of variation by age and sex have been …

Brain metabolism perturbation can contribute to traits and diseases. We conducted the first
large-scale CSF and brain genome-wide association studies, which identified 219 …

INTRODUCTION This study aimed to investigate the influence of the overall Alzheimer's
disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and …

Background: Research on peripheral (eg, blood-based) biomarkers for psychiatric illness
has typically been low-throughput in terms of both the number of subjects and the range of …