Monoclonal antibodies (mAbs) are a fast-growing class of biopharmaceuticals. They are
widely used in the identification and detection of cell makers, serum analytes, and …

Failures surrounding pharmaceutical quality, particularly with respect to product
manufacturing issues and facility remediation, account for the majority of drug shortages and …

The increased interest in using monoclonal antibodies (mAbs) as a platform for
biopharmaceuticals has led to the need for new analytical techniques that can precisely …

Two-dimensional (2D) 1H–13C methyl NMR provides a powerful tool to probe the higher
order structure (HOS) of monoclonal antibodies (mAbs), since spectra can readily be …

The extensive analytical characterization of protein biotherapeutics, especially of
biosimilars, is a critical part of the product development and registration. High-resolution …

Lipoprotein profiling of human blood by 1H nuclear magnetic resonance (NMR)
spectroscopy is a rapid and promising approach to monitor health and disease states in …

Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins
designed to bind pharmacological targets are covalently linked or expressed as fusion …

Resonance assignment and structural characterization of pharmacologically relevant
proteins promise to improve understanding and safety of these proteins by rational design …

Biosimilar drug products must have a demonstrated similarity with respect to the reference
product's molecules in order to ensure both the effectiveness of the drug and the patients' …

Biopharmaceuticals such as monoclonal antibodies are required to be rigorously
characterized using a wide range of analytical methods. Various material properties must be …