Polymer–drug conjugate therapeutics: advances, insights and prospects
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
Engineered nanomedicines with enhanced tumor penetration
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
Smart transformable nanoparticles for enhanced tumor theranostics
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …
influence their biological behaviors. In the past, nanoparticles with constant physical …
An NIR Discrete Metallacycle constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for imaging‐guided cancer Radio‐chemotherapy
Y Ding, Z Tong, L Jin, B Ye, J Zhou, Z Sun… - Advanced …, 2022 - Wiley Online Library
To promote the clinical theranostic performances of platinum‐based anticancer drugs,
imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be …
imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be …
Rational design of cancer nanomedicine: nanoproperty integration and synchronization
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …
Enzyme responsive drug delivery systems in cancer treatment
Recent technological approaches in drug delivery have attracted scientist interest for
improving therapeutic index of medicines and drug compliance. One of the powerful …
improving therapeutic index of medicines and drug compliance. One of the powerful …
MnO2-Based Nanomotors with Active Fenton-like Mn2+ Delivery for Enhanced Chemodynamic Therapy
J Ou, H Tian, J Wu, J Gao, J Jiang, K Liu… - … Applied Materials & …, 2021 - ACS Publications
Chemodynamic therapy (CDT) is an emerging strategy for cancer treatment based on
Fenton chemistry, which can convert endogenous H2O2 into toxic· OH. However, the limited …
Fenton chemistry, which can convert endogenous H2O2 into toxic· OH. However, the limited …
Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles
Nanocarriers have been widely employed in preclinical studies and clinical trials for the
delivery of anticancer drugs. The most important causes of failure in clinical translation of …
delivery of anticancer drugs. The most important causes of failure in clinical translation of …
Tumor-penetrating nanoparticles for enhanced anticancer activity of combined photodynamic and hypoxia-activated therapy
Poor tumor penetration is a major challenge for the use of nanoparticles in anticancer
therapy. Moreover, the inability to reach hypoxic tumor cells that are distant from blood …
therapy. Moreover, the inability to reach hypoxic tumor cells that are distant from blood …