TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …

Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …

Although it has long been recognized that inflammation, a consequence of immune‐driven
processes, significantly impacts bone turnover, the degree of centralization of skeletal and …

Osteoclasts are multinucleated cells of hematopoietic origin which are unique in their ability
to resorb bone. Osteoclasts are generated from myeloid progenitors through a progression …

Recently, several decoy molecules belonging to tumor necrosis factor receptor superfamily
(TNFRSF) have been identified, including decoy receptor 1 (DcR1), decoy receptor 2 …

Objective. Biomarkers may be helpful in screening patients with psoriasis for PsA. Our
purpose was to identify serum biomarkers for psoriasis and PsA. Methods. Fifty-two patients …

Aseptic loosening of total joint replacements is driven by the reaction of macrophages to
foreign body particles released from the implant. It was hypothesized that the macrophages' …

Aims/hypothesis Our aims were to compare osteoclastic activity between patients with acute
Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of …

Osteoclasts are functional cells required for bone resorption. They are derived from
hematopoietic precursors and undergo a series of differentiation and fusion steps in …