Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases
family, of which main function is to mediate bone resorption. Currently, CatK is among the …

Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy
individuals. These granulated cells preferentially leave the circulation and marginate to …

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian
metamorphosis, yet they have attracted more attention because of their roles in disease …

Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

Recent years have seen several advances in our understanding of immunity to virus
infection of the lower respiratory tract, including to influenza virus infection. Here, we review …

IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class
II expression, promoted IgE class switching and inhibited inflammatory cytokine production …

To investigate the role of immune cells in lung regeneration, we used a unilateral
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …

Introduction Chronic obstructive pulmonary disease (COPD) is a progressive disorder that
makes the breathing difficult and is characterized by pathological conditions ranging from …