Macrophages in lung injury, repair, and fibrosis
P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …
IL-4 and IL-13: regulators and effectors of wound repair
JE Allen - Annual review of immunology, 2023 - annualreviews.org
Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …
Cathepsin K: the action in and beyond bone
R Dai, Z Wu, HY Chu, J Lu, A Lyu, J Liu… - Frontiers in cell and …, 2020 - frontiersin.org
Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases
family, of which main function is to mediate bone resorption. Currently, CatK is among the …
family, of which main function is to mediate bone resorption. Currently, CatK is among the …
Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity
Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy
individuals. These granulated cells preferentially leave the circulation and marginate to …
individuals. These granulated cells preferentially leave the circulation and marginate to …
Matrix metalloproteinases and the regulation of tissue remodelling
Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian
metamorphosis, yet they have attracted more attention because of their roles in disease …
metamorphosis, yet they have attracted more attention because of their roles in disease …
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …
only recently been extensively explored from a cellular and molecular perspective. There is …
Regulating the adaptive immune response to respiratory virus infection
TJ Braciale, J Sun, TS Kim - Nature Reviews Immunology, 2012 - nature.com
Recent years have seen several advances in our understanding of immunity to virus
infection of the lower respiratory tract, including to influenza virus infection. Here, we review …
infection of the lower respiratory tract, including to influenza virus infection. Here, we review …
IL-13 effector functions
TA Wynn - Annual review of immunology, 2003 - annualreviews.org
IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class
II expression, promoted IgE class switching and inhibited inflammatory cytokine production …
II expression, promoted IgE class switching and inhibited inflammatory cytokine production …
Recruited monocytes and type 2 immunity promote lung regeneration following pneumonectomy
To investigate the role of immune cells in lung regeneration, we used a unilateral
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …
Experimental animal models for COPD: a methodological review
V Ghorani, MH Boskabady, MR Khazdair… - Tobacco induced …, 2017 - Springer
Introduction Chronic obstructive pulmonary disease (COPD) is a progressive disorder that
makes the breathing difficult and is characterized by pathological conditions ranging from …
makes the breathing difficult and is characterized by pathological conditions ranging from …