Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson's
disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors …

Macroautophagy decreases with age, and this change is considered a hallmark of the aging
process. It remains unknown whether mitophagy, the essential selective autophagic …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects around
2% of individuals over 60 years old. It is characterised by the loss of dopaminergic neurons …

Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of
origin and in terms of function. Mitochondria and peroxisomes can also be turned over by …

Parkinson's disease (PD) is a major and progressive neurodegenerative disorder, yet the
biological mechanisms involved in its aetiology are poorly understood. Evidence links this …

Selective autophagy of mitochondria, mitophagy, is linked to mitochondrial quality control
and as such is critical to a healthy organism. We have used a CRISPR/Cas9 approach to …

The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of
damaged mitochondria. We present the characterisation of an N-cyano pyrrolidine …

Much effort has been devoted to the development of selective inhibitors of the LRRK2 as a
potential treatment for LRRK2 driven Parkinson's disease. In this study, we first compare the …

Mitophagy removes defective mitochondria via lysosomal elimination. Increased mitophagy
coincides with metabolic reprogramming, yet it remains unknown whether mitophagy is a …