Contributions of human enzymes in carcinogen metabolism
S Rendic, FP Guengerich - Chemical research in toxicology, 2012 - ACS Publications
Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update
SP Rendic, FP Guengerich - Archives of toxicology, 2021 - Springer
This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
Profiling the expression of cytochrome P450 in breast cancer
GI Murray, S Patimalla, KN Stewart, ID Miller… - …, 2010 - Wiley Online Library
Murray GI, Patimalla S, Stewart KN, Miller ID & Heys SD (2010) Histopathology 57, 202–211
Profiling the expression of cytochrome P450 in breast cancer Aims: The cytochrome P450s …
Profiling the expression of cytochrome P450 in breast cancer Aims: The cytochrome P450s …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2005 - Springer
Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …
when done with experimental animals and microorganisms. Research with the human …
Drug bioactivation covalent binding to target proteins and toxicity relevance
A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
[HTML][HTML] Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
P Wegman, L Vainikka, O Stål, B Nordenskjöld… - Breast Cancer …, 2005 - Springer
Background Tamoxifen is widely used as endocrine therapy for oestrogen-receptor-positive
breast cancer. However, many of these patients experience recurrence despite tamoxifen …
breast cancer. However, many of these patients experience recurrence despite tamoxifen …
Pharmacogenomics of tamoxifen therapy
H Brauch, TE Murdter, M Eichelbaum… - Clinical …, 2009 - academic.oup.com
Background: Tamoxifen is a standard endocrine therapy for the prevention and treatment of
steroid hormone receptor–positive breast cancer. Content: Tamoxifen requires enzymatic …
steroid hormone receptor–positive breast cancer. Content: Tamoxifen requires enzymatic …
[HTML][HTML] Molecular mechanisms of anti-estrogen therapy resistance and novel targeted therapies
Simple Summary Estrogen receptor-positive (ER+) breast cancer is a notable cause of
global death from breast cancer in premenopausal and postmenopausal women. Lethality is …
global death from breast cancer in premenopausal and postmenopausal women. Lethality is …
CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development
G Luo, T Guenthner, LS Gan… - Current drug …, 2004 - ingentaconnect.com
Cytochrome P450 3A4 (CYP3A4), an enzyme that is highly expressed in the human liver
and small intestine, plays a major role in the metabolism of a large variety of xenobiotics …
and small intestine, plays a major role in the metabolism of a large variety of xenobiotics …