Abstract Modafinil (2-[(Diphenylmethyl) sulfinyl] acetamide, Provigil) is an FDA-approved
medication with wake-promoting properties. Pre-clinical studies of modafinil suggest a …

The prefrontal cortex (PFC) mediates a range of higher order 'executive functions' that
subserve the selection and processing of information in such a way that behavior can be …

Prefrontal cortical executive functions comprise a number of cognitive capabilities necessary
for goal directed behavior and adaptation to a changing environment. Executive dysfunction …

Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent
kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating …

It has been established that sleep deprivation (SD) reduces the proliferation of neuronal
precursors in the adult hippocampus. It has also been reported that psychostimulant drugs …

Background There is growing debate on the use of drugs that promote cognitive
enhancement. Amphetamine-like drugs have been employed as cognitive enhancers, but …

The number of individuals affected by psychostimulant use disorder (PSUD) has increased
rapidly over the last few decades resulting in economic, emotional, and physical burdens on …

Pupil diameter has long been used as a metric of cognitive processing. However, recent
advances suggest that the cognitive sources of change in pupil size may reflect LC-NE …

Modafinil has been shown to promote wakefulness and some studies suggest the drug can
improve cognitive function. Because of many similarities, the mechanism of action may be …

One of the hallmarks of decision-making processes is the inter-individual variability between
healthy subjects. These behavioral patterns could constitute risk factors for the development …