To initiate DNA replication, it is essential to properly assemble a pair of replicative helicases
at each replication origin. While the general principle of this process applies universally from …

Rift Valley fever virus (RVFV) belongs to the order Bunyavirales and is the type species of
genus Phlebovirus, which accounts for over 50% of family Phenuiviridae species. RVFV is …

Many cancer-driving protein targets remain undruggable due to a lack of binding molecular
scaffolds. In this regard, octahedral metal complexes with unique and versatile three …

Error‐free genome duplication and accurate cell division are critical for cell survival. In all
three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication …

Human DNA licensing initiates the process of replication fork assembly. Specifically, this
reaction leads to the loading of hMCM2-7 on DNA, which represents the core of the …

Origin recognition complex (ORC) binds to replication origins in eukaryotic DNAs and plays
an important role in replication. Although yeast ORC is known to sequence-specifically bind …

Autonomously replicating sequences (ARSs) are important accessories in episomal vectors
that allow them to be replicated and stably maintained within transformants. Despite their …

DNA replication is a complicated process involving several dozens of factors. The molecular
machine of eukaryotic DNA replication, replisome, consists of at least three essential …

Cycling of cells requires duplication of the genetic information which is encoded in the DNA.
During the S-phase of the cell cycle, when DNA replication occurs, cells have to tolerate …

Coordinated initiation of DNA replication is essential to ensure efficient and timely DNA
synthesis. Yet, the mechanism governing the “initiation” process in eukaryotic cells remains …