The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

Polyphenol compounds are natural antioxidants, which are rich in anti-inflammatory and
antioxidant components. They have a wide range of medicinal benefits that are believed to …

Cholangiocarcinoma (CCA) is a deadly disease. While surgery may attain cure in a minor
fraction of cases, therapeutic options in either the adjuvant or advanced setting are limited …

Interest has grown in studying the possible use of well-known anti-diabetic drugs as anti-
cancer agents individually or in combination with, frequently used, chemotherapeutic agents …

Signal transducers and activators of transcription 3 (STAT3) signaling plays an important
role in mediating tumor progression, inflammation, cardiovascular disease, and other …

Tumor heterogeneity impinges on all the aspects of tumor history, from onset to metastasis
and relapse. It is growingly recognized as a propelling force for tumor adaptation to …

Metastasis leads to poor prognosis and reduced disease-free survival in breast cancer
patients, particularly in those with triple-negative breast cancer (TNBC) which is resistant to …

Liver fibrosis is a disease with significant morbidity and mortality. It is a chronic pathological
process characterized by an imbalance of extracellular matrix production and degradation in …

Cholangiocarcinoma (CCA) is an aggressive biliary epithelial tumor with limited therapeutic
options and poor prognosis. Curcumin is a promising active natural compound with several …

The safety windows and toxicity of clinically available known drugs allow drug repurposing
to be a popular treatment strategy for several diseases, including cancers. Several common …