Dilated cardiomyopathy: genetic determinants and mechanisms

EM McNally, L Mestroni - Circulation research, 2017 - Am Heart Assoc
Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

Left ventricular diastolic function: understanding pathophysiology, diagnosis, and prognosis with echocardiography

SF Nagueh - JACC: Cardiovascular Imaging, 2020 - jacc.org
Left ventricular diastolic function plays an important role in determining left ventricular filling
and stroke volume. Abnormal diastolic function has been recognized in many cardiovascular …

Heart failure with preserved ejection fraction: insights into diagnosis and pathophysiology

SF Nagueh - Cardiovascular Research, 2021 - academic.oup.com
Heart failure with preserved ejection fraction (HFpEF) accounts for at least half the cases of
heart failure, currently diagnosed. There are several cardiac and non-cardiac manifestations …

Advances in echocardiographic imaging in heart failure with reduced and preserved ejection fraction

AMS Omar, M Bansal, PP Sengupta - Circulation research, 2016 - Am Heart Assoc
Echocardiography, given its safety, easy availability, and the ability to permit a
comprehensive assessment of cardiac structure and function, is an indispensable tool in the …

Heart failure in end-stage kidney disease: pathophysiology, diagnosis, and therapeutic strategies

J Rangaswami, PA McCullough - Seminars in nephrology, 2018 - Elsevier
Heart failure (HF) is a major comorbidity in patients with end-stage kidney disease (ESKD).
The pathogenesis of HF in patients on renal replacement therapy represents the confluence …

Assessment of myocardial fibrosis using two-dimensional and three-dimensional speckle tracking echocardiography in dilated cardiomyopathy with advanced heart …

J Wang, Y Zhang, L Zhang, F Tian, B Wang, Y Xie… - Journal of Cardiac …, 2021 - Elsevier
Background This study aimed to depict strain parameters derived from 2-dimensional (2D)-
and 3-dimensional (3D) speckle tracking echocardiography and to explore which may best …

Right ventricular longitudinal strain in patients with heart failure

M Ji, W Wu, L He, L Gao, Y Zhang, Y Lin, M Qian… - Diagnostics, 2022 - mdpi.com
Patients with heart failure (HF) have high morbidity and mortality. Accurate assessment of
right ventricular (RV) function has important prognostic significance in patients with HF …

Myocardial tissue characterisation using echocardiographic deformation imaging

MA Moharram, RR Lamberts, G Whalley… - Cardiovascular …, 2019 - Springer
Myocardial pathology results in significant morbidity and mortality, whether due to primary
cardiomyopathic processes or secondary to other conditions such as ischemic heart …

Epigenetic-sensitive liquid biomarkers and personalised therapy in advanced heart failure: a focus on cell-free DNA and microRNAs

G Mansueto, G Benincasa, N Della Mura… - Journal of Clinical …, 2020 - jcp.bmj.com
Dilated cardiomyopathy (DCM) represents a common genetic cause of mechanical and/or
electrical dysfunction leading to heart failure (HF) onset for which truncating variants in titin …

Relation of left ventricular diastolic function to global fibrosis burden: implications for heart failure risk stratification

D Lewandowski, EY Yang, DT Nguyen, MA Khan… - Cardiovascular …, 2023 - jacc.org
Background Left ventricular (LV) diastolic function is primarily assessed by means of
echocardiography, which has limited utility in detecting fibrosis. Cardiac magnetic …