Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Mental disorder classification provides a definitional framework that underlies applied
clinical and research efforts to understand, assess, predict, prevent and ameliorate the …

A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Background Whilst apps and e-tools have tremendous potential as low-cost, scalable mental
health intervention and prevention tools, it is essential that consumers and health …

Background Subthreshold depression is highly prevalent in adolescence, but compared to
major depressive disorder, the clinical impact is under-researched. The aim of this review …

Human-computer interaction (HCI) has contributed to the design and development of some
efficient, user-friendly, cost-effective, and adaptable digital mental health solutions. But HCI …

Preventive interventions that are effective in reducing the incidence of mental disorders in
adolescence and early adulthood may impact substantially on lifetime economic …

Objective: The early intervention service (EIS) model for psychosis has been implemented
with increasing frequency; yet, improving outcomes across domains for all patients remains …

Background The global burden of anxiety and depression has created an urgent need for
scalable approaches to increase access to evidence-based mental health care. The …

Aims Many young people with mental health and/or substance use concerns do not have
access to timely, appropriate, and effective services. Within this context, stepped care …