The p53 gene is the most frequently mutated gene in human cancer. The identification of two
homologues, p63 and p73, revealed that p53 is a member of a family of related transcription …

As p53 and its homologue p73 have significant sequence and functional similarities, p73
might also be expected to act as a tumour suppressor. However, p73 is activated after DNA …

The p53 protein is related by sequence homology and function to the products of two other
genes, p63 and p73, that each encode several isoforms. We and others have discovered …

Inactivation of the tumour suppressor p53 is the most common defect in cancer cells. The
discovery of its two close relatives, p63 and p73, was therefore both provocative and …

Abstract p53 and its related genes, p63 and p73 constitute the p53 gene family. While p53 is
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …

Abstract p73, a recently identified gene highly homologous to p53, can transactivate p53
target genes and induce apoptosis. Here we report the identification of an NH2-terminal …

Resistance to radio-and chemotherapy is a major problem in treatment responses of lung
cancer. In this disease, biological markers, that can be predictive of response to treatment for …

Simple Summary The p53 family is a complex family of transcription factors with different
cellular functions that are involved in several physiological processes. A massive amount of …

The p53 homologue p63 is essential for ectodermal differentiation, such that p63−/− mice
lack all squamous epithelia and teeth. The p63 gene expresses at least 6 different …

p73 and p63 are recently cloned genes that share considerable structural and functional
homologies with the p53 tumor suppressor gene. These genes, unlike p53, express multiple …